Endpoints Working Group

Angela Dispenzieri, M.D., is a consultant in the Division of Hematology, Department of Internal Medicine at Mayo Clinic. She has joint appointments in the Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, and the Department of Molecular Medicine. Dr. Dispenzieri holds the academic rank of Professor of Medicine and of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, and she is recognized with the distinction of a named professorship, the Serene M. and Frances C. Durling Professorship. She joined the staff of Mayo Clinic in 1998 and served as Chair of Hematology Research from 2014 to 2022. She served as the President of the International Society of Amyloidosis from 2016 to 2018, and currently chairs the Mayo Clinic Amyloid Interest Group.

Michelle is a senior researcher and leader with more than 20 years of experience in patient-centered research and outcome measurement, including the development, modification, and evaluation of patient-reported outcome (PRO) measures and other clinical outcome assessments (COA). She has led or advised on 80+ studies that have included qualitative, quantitative, and mixed method research methodologies, including measurement strategy for regulatory engagement, dossier development, landscape and gap analysis, patient preference, observational studies, meta-analyses, in-trial interviews, and others across a broad range of rare and prevalent conditions; and research on the of technology and eCOA, including novel approaches to make it easier for patients and their families to participate in research studies. Her expertise includes strategic consultation and preparation for regulatory meetings and submissions to support product labeling based on COA endpoints. Prior to joining QM in 2008, Michelle conducted addiction treatment outcome studies and supported a comprehensive assessment system for addiction and mental health treatment. She has also held adjunct positions at Illinois State University and the University of Illinois, where she earned her master’s degree and PhD in sociology, respectively.